Xanthogranulomatous cholecystitis (XGC) is an uncommon The files of the department of histopathology at the. Royal Hallamshire Hospital. Xanthogranulomatous cholecystitis is a rare inflammatory disease of in a review of 40 cases from the Armed Forces Institute of Pathology [3]. General. Uncommon ~ %. Approximately 2% in one series of gallbladders. May be confused (clinically) with gallbladder carcinoma.

Author: Kazrajas Faujin
Country: Montserrat
Language: English (Spanish)
Genre: Business
Published (Last): 1 September 2006
Pages: 424
PDF File Size: 13.15 Mb
ePub File Size: 6.17 Mb
ISBN: 326-4-79676-770-7
Downloads: 88805
Price: Free* [*Free Regsitration Required]
Uploader: Kajibar

XGC is characterized grossly by irregular wall thickening of the gallbladder associated with the formation of yellowish nodules.

The pathogenesis of XGC is uncertain, but histologic evidence of chronic inflammation is generally seen and gallstones are present in a large majority of cases. CASE A year-old male was admitted to our hospital with a day history of right upper quadrant pain with fever.

XGC may be difficult to distinguish clinically from acute or chronic cholecystitis; radiologically, it is difficult to distinguish from gallbladder cancer.

Despite the possible association between XGC fholecystitis gallbladder cancer, XGC is not believed to be a premalignant lesion Hiistopathology cholecystitis ; Gallbladder cancer.

Retrieved from ” https: Microscope – Seeing the Unseen. Magnetic resonance imaging MRI demonstrated diffuse wall thickening of the gallbladder by viewing high signal foci with signal void lesions. We report a case with XGC mimicking gallbladder cancer in a hemophilia patient.


This entity was first described in by Christen and Ishak as fibroxanthogranulomatous inflammation 1. This unusual entity is characterized morphologically by a broad spectrum of xanthogranulomatous changes seen from a small limited focus within yellow nodule in the gallbladder wall, to diffuse involvement of the entire gallbladder with extension of the fibrosis into surrounding tissues.

However, as XGC has the potential for fistula formation, Robert et al 6. Xanthogranulomatous cholecystitis mimicking gallbladder cancer: Fligial S, Lewin KJ.

There was a problem providing the content you requested

A clinical and pathologic study of twelve cases. After factor VIII replacement, exploration was done.

Sign up for our Email Newsletters. Acta Pathol Jpn ; Coagulation profiles were PT There was no regional lymph node enlargement or focal mass in the liver. Eur J Radiol 82 9: Xanthogranulomatous cholecystitis may form a tumour-like mass in inflamed gallbladders. Gastroenterol Res Pract It means that both XGC and gallbladder cancer are complications of gallstone and inflammation of the gallbladder, or it may suggest that tissue disruption by cancer facilitates extravasation of bile into the gallbladder wall J Clin Pathol ; More recently, these terms, together with other labels, such as ceroid granuloma, ceroid-like histiocytic granuloma of the gallbladder 2 and biliary granulomatous cholecystitis 3have been abandoned in favor of XGC, a descriptive term first used by McCoy et al 4.


Xanthogranulomatous cholecystitis. Histopathological study and classification.

Accessed December 31st, Cross sections through the wall revealed multiple yellow-colored, nodule-like lesions ranging from 0. Occasionally, XGC may closely mimic a gallbladder cancer or lead to complications such as perforation, abscess and fistula. Clinico-pathological study of xanthogranulomatous cholecystitis. Previous reports have suggested that the important process is the extravasation of bile into the gallbladder wall, either from ruptured Rokitansky-Aschoff sinuses or focal mucosal ulceration 2histoppathology.

Postgrad Med J ; On intraoperative cholangiogram through the cystic duct after cholecystectomy, there was no evidence of remaining stone or bile duct dilatation. Perfidious gallbladders – a diagnostic dilemma with xanthogranulomatous cholecystitis. The precursor lesions of invasive gallbladder carcinoma. Pathol Res Pract ; The Korean Journal of Oc Medicine ;14 2: Epidemiology of xanthogranulomatous cholecystitis.

Retrospective analysis of 12 cases. A retrospective Cohort study. Hepatobiliary Pancreat Dis Int. Nippon Geka Gakkai Zasshi.

Xanthogranulomatous cholecystitis – Libre Pathology

Computed tomogram CT revealed a well-marginated, uniform, marked wall thickening of the gallbladder with multiseptate enhancement Fig.

Also, there appears to be a positive association between the two lesions. Views Read View source View history.