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ERTAPENEM PACKAGE INSERT PDF

For Package Inserts, please click on the NDC#. Presentation(s):1g; Reference Listed Drug:Invanz®; Therapeutic Class: Antibacterial, carbapenem type. INVANZ 1 g powder for concentrate for solution for infusion. 2. . This medicinal product contains approximately mEq (approximately mg) of sodium per g dose which should Package Leaflet: information for the user. INVANZ 1 . Product Availability · Contact Us · Make An Inquiry. () Product Summary. Ertapenem Sodium Injection. Therapeutic Class: Carbapenem Antibiotic.

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Surgical intervention is the primary therapeutic intervention. For the treatment of complicated urinary tract infection UTI pyelonephritisincluding cases with concurrent bacteremia.

Ertapenem for Injection — AuroMedics Pharma LLC

Practitioners should be aware that antibiotic-associated colitis has been observed to occur over two months or more following discontinuation of systemic antibiotic therapy; a careful medical history should ertapene taken. IM use is contraindicated in patients with an amide packaeg anesthetic hypersensitivity. May consider IM administration as an alternative to IV administration in the treatment of infections where IM therapy is appropriate; however, only administer via IM injection for 7 days.

Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. In the colon, overgrowth of Clostridia may exist when normal flora is altered subsequent to eryapenem administration.

Ertapenem is suggested as an option for moderate to severe diabetic wound infections. Affected cytochrome P isoenzymes: Major Concomitant use of carbapenems doripenem, ertapenem, imipenem, meropenem and valproic acid is not recommended.

Infuse IV over 30 minutes. It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs.

Carbapenem ertapenme, cephalosporin hypersensitivity, penicillin hypersensitivity. Ertapenem is administered via intravenous IV or intramuscular IM routes. Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases. Data regarding progestin-only contraceptives or for newer combined contraceptive deliveries e.

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Antibiotic therapy should be administered until further debridement is not necessary, the patient has improved clinically, and fever has been absent for 48 to 72 hours. No intraoperative redosing and duration of prophylaxis less than 24 hours are suggested by clinical practice guidelines.

Therefore, these antibiotics should be taken at least 2 hours before and not less than 6 hours after the administration of sodium picosulfate; insertt oxide; anhydrous citric acid solution. Ertapenem is excreted in human breast milk. Ertapenem, in combination with an agent for atypical pathogens, is considered an acceptable alternative beta-lactam alternative for hospitalized patients with risk factors for infection with gram-negative pathogens other than Pseudomonas aeruginosa.

However, the elimination half-life of ertapenem is increased only from 4 to 4. Ertapenem has a short PAE of 1. Another review concurred with these data, but noted that individual patients have been ertapeneem who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, tetracyclines, and penicillin derivatives.

Ertapenem is structurally similar to the penicillins and cephalosporins and these patients may be more susceptible to hypersensitivity reactions. However, it is insegt that a combination of resistance mechanisms is required for significant carbapenem resistance. Use within 1 hour after preparation. Infants and Children 3 months to 12 years.

Theoretically, efflux activity plus loss of membrane permeability is less likely to happen in vivo than AmpC beta-lactamase expression and loss of membrane permeability.

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Ertapenem for Injection

Agitate well to form a solution. Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in inssrt with antibiotics. One retrospective study reviewed the literature to inzert the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which ergapenem incidence of pregnancy with OCs and antibiotics was reported.

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Further dilution is necessary for IV infusion. IV or IM broad-spectrum carbapenem antibiotic stable against beta-lactamases Used to treat UTI, skin, pelvic, intraabdominal infections and community-acquired pneumonia; used for colorectal surgical prophylaxis Once-daily dosing may be advantageous, but no P.

For less than 1 g dose: Ertapenem is also recommended for incisional surgical site infections of the intestinal or genitourinary tract. Send the page ” ” to a friend, relative, colleague or yourself.

Ertapenem Sodium Injection – Par Sterile Products – Products

PAE is defined as the suppression of bacterial growth that continues after the antibiotic concentration falls inseert the bacterial MIC. Prescribing ertapenem in the absence of a proven or strongly suspected bacterial infection or for a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

Following diagnosis of pseudomembranous colitis, therapeutic measures should be instituted. Dilute the entire contents of the reconstituted vial in 50 mL of 0. Ertapenem is not a substrate for P-glycoprotein mediated transport. Moderate The concomitant use of warfarin with many classes of antibiotics, including carbapenems, may result in an increased INR thereby potentiating the risk for bleeding.

Other dosage adjustment guidelines for adults: In milder cases, the colitis may respond to discontinuation of the offending agent. Inhibition of vitamin K synthesis due to alterations in the intestinal flora may be a mechanism; however, concurrent infection is also a potential risk factor for elevated INR. Dilute the appropriate volume of the reconstituted solution based on body weight in 0.